It contains a firefly luciferase gene driven by four copies of the nf κb response element located upstream of the minimal tata promoter. As a result thp1 dual cells allow the simultaneous study of the nf κb pathway by monitoring the activity of seap and the irf pathway by assessing the activity of a secreted luciferase lucia. Thp1 dual cells were derived from the human thp 1 monocyte cell line by stable integration of two inducible reporter constructs.
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